When Dr. Elias K. Michaelis presented his mitochondria genome relevant work, I was curious whether he will present some findings whether mitochondria has its own TDP-43. I have not seen it in Dr. Michaelis presentation. Now, the Nature Medicine which I posted already, emphasize the delirious impact of TDP-43 accumulation in mitochondria. What does TDP-43 do in mitochondria? Since TDP-43 has a RNA-binding domain, it inhibits the translation of the respiratory complex-I sub-units ND3 and ND6. Well, how does TDP-43 gets in mitochondria? Probably through transporters. Which one? That is why we need to figure it out.
Comments