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Hi, I am interested about role of mitochondrial function in trophoblast cell lineage development, which is essential for establishment of a successful pregnancy. Unfortunately, our understanding of mitochondrial biology in the context of trophoblast cell lineage is extremely poor. Interestingly, in early preimplantation embryos, trophectoderm cells undergo metabolic switch and uses OXPHOS to generate more ATP. This ensures formation of a matured blastocyst. We have started  working on this aspect using mouse trophoblast stem cells and mouse embryos as model systems. However, we want to explore contribution of mitochondrial dysfunction in real patients, who experienced miscarriage or are affected by pathological pregnancies like, preeclampsia, gestational diabetes mellitus, or IUGR.  I will encourage suggestions, discussions about science and potential funding.